Presenter: Dr. Jennifer Huen, University of Toronto
Topic: Targeted method for control Salmonella enterica in broilers using single domain antibody-based approach
Novel control strategies are necessary for the expansive market of broiler chickens, due to the elevating colonization rates of Salmonella enterica in combination with ban on antibiotic usage in most regions. We propose the use of targeted single domain antibodies (sdAbs) to reduce the colonization load of S. enterica in broiler chickens.
About Dr. Huen
Jennifer Huen’s goal is to produce better antibody therapeutics to reduce pathology in livestock brought on by microbials or toxins. She conducts computational modeling of interactions between antibodies and their antigens and predictions of the biophysical behaviors of these antibodies. These analyses direct the rational design of antibodies with specific characteristics which, with her background in structural biology and protein biochemistry, she generates as antibody prototypes for testing. So far, 11 prototypes have been produced in which 2 demonstrated enhanced antigen binding in the lab and enhanced pathogen reduction in field trials. She finds this work exciting and rewarding.
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