Presenter: Dr. Soroush Samadian, Cyclica
Topic: Genetic variation and structure-based drug polypharmacology: multiscale structural pharmacogenomics
Over the past decade, genome-wide association studies (GWAS) have aimed to identify the genomic causes of variability in drug-response among different individuals and populations. With the exception of few diseases, the observed drug-response is a consequence of an intricate interplay between multitudes of genetic variants. As such, precise identification of a small number of variants (among many) that are casual to the drug response among many variants remains challenging. To address this challenge, many prioritization tools and algorithms have been developed over the past few years, leading to significant progress in the field. However, to date, information pertaining to the 3D structural proteome and its relation to drug binding sites has not been systematically leveraged to improve pharmacogenetic analyses.
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